The Americas were thought to have been first inhabited by people crossing the Bering Land Bridge, now known as the Bering strait, from northeast Asia into Alaska well over 10,000 years ago. The earliest known settlement, however, was identified at Monte Verde, near Puerto Montt in Southern Chile. Its occupation dates to some 14,000 years ago and there is some disputed evidence of even earlier occupation. Over the course of millennia, people spread to all parts of the continents. By the first millennium AD/CE, South America's vast rainforests, mountains, plains and coasts were the home of tens of millions of people. The earliest settlements in the Americas are of the Las Vegas Culture^[19] from about 8000 BC and 4600 BC, a sedentary group from the coast of Ecuador, the forefathers of the more known Valdivia culture, of the same era. Some groups formed more permanent settlements such as the Chibchas (or "Muiscas" or "Muyscas") and the Tairona groups. These groups are in the circum Caribbean region. The Chibchas of Colombia, the Quechuas and Aymaras of Bolivia and Perú were the three indigenous groups that settled most permanently.

The region was home to many indigenous peoples and advanced civilizations, including the Aztecs, Toltecs, Caribs, Tupi, Maya, and Inca. The golden age of the Maya began about 250, with the last two great civilizations, the Aztecs and Incas, emerging into prominence later on in the early fourteenth century and mid-fifteenth centuries, respectively. The Aztec empire was ultimately the most powerful civilization known throughout the Americas, until its downfall in part by the Spanish invasion.

European colonization

With the arrival of the Europeans following Christopher Columbus's voyages, the indigenous elites, such as the Incas and Aztecs, lost power to the heavy European invasion. Hernándo Cortés seized the Aztec elite's power with the help of local groups who did not favor the Aztec elite, and Francisco Pizarro eliminated the Incan rule in Western South America. The European powers of Spain and Portugal colonized the region, which along with the rest of the uncolonized world, was divided into areas of Spanish and Portuguese control by the line of demarcation in 1493, which gave Spain all areas to the west, and Portugal all areas to the east (the Portuguese lands in South America subsequently becoming Brazil). By the end of the sixteenth century Spain and Portugal had been joined by others, including France, in occupying large areas of North, Central and South America, ultimately extending from Alaska to the southern tips of the Patagonia. European culture, customs and government were introduced, with the Roman Catholic Church becoming the major economic and political power to overrule the traditional ways of the region, eventually becoming the only official religion of the Americas during this period.